CD105 (Endoglin, gp160, TGF beta1,3 Receptor) (PE)

Human CD105 (endoglin) is a homodimeric membrane glycoprotein virtually restricted to endothelial cells, and present on some leukemia cells and minor subsets of bone marrow cells. CD105 binds to TGF-b1 and b3 with high affinity.\n\nFunctional Application: Antibody will augment binding of TGF-b1 to CD105 expressing leukemia cells.\n\nApplications: \nSuitable for use in Flow Cytometry, Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only pror to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.

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SPECIFICATIONS

Catalog Number

C2446-50E3

Size

120Tests

Applications

FC, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 50mM Sodium Phosphate pH 7.5, 500mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

References

1. Y. Haruta & B.K. Seon, (1986) Proc Natl Acad Sci USA 83: 7898-7902. \n2. H. Hara, et al, (1988)Cancer Res 48: 4673-4680. \n3. W.C. Biddle, et al, (1989) Leukemia Res 13: 699-707. \n4. S. Cheifetz, et al, (1992) J Biol Chem 267: 19027-19030. \n5. B.K. Seon, et al, (1995) Proc Am Assoc Can Res 36: 23. \n6. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1756-1761, 1762-1764. \n7. B.K. Seon, et al (1996) Tissue Antigens 48: 417.

Additional Info

Recognizes a CD105 homodimer with a molecular weight of about 160kD.