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CD106 (Vascular Cell Adhesion Protein 1, V-CAM 1, VCAM-1, INCAM-100, L1CAM, VCAM1)

CD106 (Vascular Cell Adhesion Protein 1, V-CAM 1, VCAM-1, INCAM-100, L1CAM, VCAM1)

Cat no: C2446-75H

Supplier: United States Biological
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CD106 is a 110kD single chain type I glycoprotein also known as VCAM-1 and INCAM-110. It is expressed predominantly on activated vascular endothelium but has also been identified on follicular and interfollicular dendritic cells, some macrophages, bone marrow stromal cells, and non-vascular cell populations within joints, kidney, muscle, heart, placenta, and brain. Expression on endothelial cells as well as many other cells is induced by inflammatory stimuli and cytokines. Activated endothelial cells can release soluble forms of CD106 which can be detected in the blood. CD106 binds the integrins CD49d/CD29 (VLA-4) and a4B7 that contribute to leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation. Applications: Suitable for use in ELISA, Immunofluorescence, Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)2ug/10e5 cells in 100ul Immunohistochemistry: acetone-fixed, frozen tissue sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2446-75H
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 2. Leca, G., et al. 1995. J. Immunol. 154:1069. 3. Yen,YT.,et al.2006. J Virol.80:2648. 4. Carlos, T., et al. 1994. Blood 84:2068. 5. Jones, E., et al. 1995. Nature 373:539.
Additional info: Recognizes human CD106.

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