CD117 (c-kit, Stem Cell Factor, SCF Receptor, Steel Factor Receptor, Mast Cell Growth Factor, MGF)

Cellular Localization: Type I membrane protein.\n\nPositive Control: Tonsil\n\nApplications: \nSuitable for use in Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

C2448-04Q

Size

500ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

PBS pH7.3

P Type

Pab

Purity

Purified

Isotype

IgG

References

This product has been used in:Arber DA et al. Paraffin section detection of the c-kit gene product (CD117) in human tissues: value in the diagnosis of mast cell disorders. Hum Pathol 29:498-504 (1998). <PUBMED:9596274> Miettinen M et al. Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol 30:1213-20 (1999). <PUBMED:10534170>Escribano L et al. Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia. Cytometry 30:98-102 (1997). <PUBMED:9149916>Oertel J et al. Immunotyping of blasts in human bone marrow. Ann Hematol 72:125-9 (1996). <PUBMED:8766253>

Additional Info

This antibody recognizes a protein of 145kD identified as CD117/p145kit. In normal cells, the CD117 antibody has been shown to label breast epithelium, germ cells, melanocytes, stem cells and mast cells. In abnormal cells, it has been shown to label testicular germ cells, endometrial carcinomas, papillary and follicular thyroid carcinomas, small cell carcinomas, melanomas and ovarian epithelial carcinomas. It has also been shown to be an effective marker for mast cell disorders, gastrointestinal stromal tumors and immunotyping of blasts in human bone marrow. Species Crossreactivity: Crossreacts with Human.

Alternative Names

CD117 antigen, C-Kit, Mast/stem cell growth factor receptor precursor, PBT, Proto-oncogene tyrosine-protein kinase Kit, SCFR, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog