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CD117 (c-kit, Stem Cell Factor, SCF Receptor, Steel Factor Receptor, Mast Cell Growth Factor, MGF)

Cat no: C2448-39


Supplier: United States Biological
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CD117, c-kit is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, breast; malignant melanoma, endodermal sinus tumor, and small cell carcinoma) but has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi
Catalogue number: C2448-39
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid in PBS, pH7.4, protein base, sodium azide.
P type: Mab
Purity: Supernatant
References: 1. Sircar K, et al. AM J Surg Pathol 23(4):377-389,1999 2. Miettinen M et al. Am J Surg Pathol 24(2):211-222, 2000 3. Miettinen M. et al. Am J Surg Pathol 23(9): 1109-1118 4. Arber DA, Tamayo R, Weiss LM. Hum Pathol 1998 May: 29(5):498-504 5. de Silva CM, Reid R. Pathol Oncol Res. 2003;9(1):13-9. Epub 2003 Apr 18 6. Naeem M et al. Hum Pathol. 2002 Dec;33(12):1182-7 7. Chen J et al. Arch Pathol Lab Med. 2001 Nov;125(11):1448-52 8. Graadt van Roggen JF et al. J Clin Pathol. 2001 Feb;54(2):96-102 9. Elmore LW et al. Arch Pathol Lab Med. 2001 Jan;125(1):146-51
Additional info: Recognizes human CD117. Staining pattern: Cytoplasmic, Membranous.

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