Home  >  Products  >  CD117 (CD117 Antigen, c-Kit, KIT, Mast/stem Cell Growth Factor Receptor, PBT, Proto-oncogene c-Kit, SCFR, Tyrosine-protein Kinase Kit)
CD117 (CD117 Antigen, c-Kit, KIT, Mast/stem Cell Growth Factor Receptor, PBT, Proto-oncogene c-Kit, SCFR, Tyrosine-protein Kinase Kit)

CD117 (CD117 Antigen, c-Kit, KIT, Mast/stem Cell Growth Factor Receptor, PBT, Proto-oncogene c-Kit, SCFR, Tyrosine-protein Kinase Kit)

Cat no: C2448-03Q

Supplier: United States Biological
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CD117, a 145kD Type III transmembrane Tyrosine Kinase receptor, is a novel member of Ig superfamily. It is a Human homolog of proto-oncogene c-Kit and is expressed in tissue mast cells and hematopoietic stem and progenitor cells. It consists of an extracellular domain with Ig-like repeats and a Tyrosine Kinase domain, a putative transmembrane region and a cytoplasmic domain. CD117 functions as receptor for MGF/SCF resulting in maturation of hemopoietic and primordial germ cell precursors and melanocytes during embryonic development. CD117 gets autophosphorylated and activates signaling pathways including PI3K/Akt, MAPK and JNK affecting multiple cellular functions including cell survival, proliferation, adhesion and differentiation. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia and piebaldism. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Cellular Localization: Cytoplasmic and cell membrane Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2448-03Q
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog, EC=2.7.10.1
References: 1. Arber et al. Hum Pathol 29: 498, 1998. 2. Rajpert et al. J Pathol 178: 166, 1996. 3. Arber et al. Hum Pathol 29: 498, 1998. 4. Rajpert et al. J Pathol 178: 166, 1996. 5. Zeng et.al Blood 105 (1) 226-232 (January 1, 2005). 6. Catalano et.al JBC 279 (45) 46706-46714 (November 5, 2004). 7. Yarden et.al EMBO J 6 (11) 3341-3351 (1987). 8. Kitamura et.al Cell Mol Life Sci 61: 2924-2931 (2004).
Additional info: Recognizes human CD117.

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