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CD117 (Mast/Stem Cell Growth Factor Receptor Kit, SCFR, Piebald Trait Protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein Kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog, KIT)

Cat no: C2448-06A

CD117 (Mast/Stem Cell Growth Factor Receptor Kit, SCFR, Piebald Trait Protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein Kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog, KIT)

CD117 is a 145kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemic cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117, and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroidcommitted and granulo-monocytic committed cells. The 104D2 antibody does not block binding of c-Kit ligand.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: (same/less than)1ug/10e6 cells in 100ul volume\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2448-06A

Size

50ug

Applications

FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG1,k

References

1. Broudy, V.C., et al. 1999. Blood 94:1979. 2. Yoshino, N., et al., 2000. Exp. Anim. 49:97. 3. Nagano, M., et al., 2007. Blood 110:151.

Additional Info

Recognizes human CD117.

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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