Home  >  Products  >  CD117 (Mast/Stem Cell Growth Factor Receptor Kit, SCFR, Piebald Trait Protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein Kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog, KIT)
CD117 (Mast/Stem Cell Growth Factor Receptor Kit, SCFR, Piebald Trait Protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein Kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog, KIT)

CD117 (Mast/Stem Cell Growth Factor Receptor Kit, SCFR, Piebald Trait Protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein Kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog, KIT)

Cat no: C2448-06B

Supplier: United States Biological
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The CD117 molecule, a tyrosine kinase receptor with a molecular weight of 145kD, is encoded by proto-oncogene c-kit. The stem cell factor (SCF) binding to the CD117/c-kit receptor triggers homodimerization and intermolecular tyrosine phosphorylation, thus initiating signal transduction. The receptor tyrosine kinase CD117/c-kit and its ligand SCF are essential to the maturation of hemopoietic, primordial germ cells precursors and melanocytes during embryonic development. Multiple cellular functions are affected by CD117/c-kit dependent signals including cell survival, proliferation, adhesion, differentiation and functional maturation of hemopoietic cells. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry: 1:400 for 10min at RT Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2448-06B
Reactivities: Human, Canine
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Elmore, L. et al. Arch Pathol Lab Med 125, 146 (2001). 2. Ahman, L. et al. Leuk Lymphoma 34, 451 (1999). 3. Broudy, V. et al. Blood 91, 898 (1998). 4. Alexander, W. et al. Leuk Res 22, 1097 (1998).
Additional info: Recognizes human CD117. Species Crossreactivity: canine.

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