Home  >  Products  >  CD119 (CD119 Antigen, CDw119, FLJ45734, Immune Interferon Receptor 1, Interferon gamma Receptor alpha Chain, Interferon gamma Receptor 1, IFN-gamma Receptor 1, IFN gamma R1, IFN-gamma-R1, IFNGR 1, IFNGR1, IFNGR) (Biotin)
CD119 (CD119 Antigen, CDw119, FLJ45734, Immune Interferon Receptor 1, Interferon gamma Receptor alpha Chain, Interferon gamma Receptor 1, IFN-gamma Receptor 1, IFN gamma R1, IFN-gamma-R1, IFNGR 1, IFNGR1, IFNGR) (Biotin)

CD119 (CD119 Antigen, CDw119, FLJ45734, Immune Interferon Receptor 1, Interferon gamma Receptor alpha Chain, Interferon gamma Receptor 1, IFN-gamma Receptor 1, IFN gamma R1, IFN-gamma-R1, IFNGR 1, IFNGR1, IFNGR) (Biotin)

Cat no: C2453-01G1

Supplier: United States Biological
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The high-affinity IFN-G receptor complex is made up of two type I membrane proteins, IFN-G R1 (IFN-G Ra) and IFN-G R2 (IFN-G Rb). Both proteins are members of the type II cytokine receptor family and share ~52% overall sequence identity. IFN-G R1 is the ligand-binding subunit that is necessary and sufficient for IFN-G binding and receptor internalization. IFN-G R2 is required for IFN-G signaling but does not bind IFN-G by itself. Human IFN-G R1 cDNA encodes a 499aa residue protein with a 17aa signal peptide, a 228aa extracellular domain, a 23aa transmembrane domain, and a 221aa intracellular domain. Human and mouse IFN-G R1 share 52aa sequence similarity and bind IFN-G in a species-specific manner. IFN-G R1 is constitutively expressed in most cell types. Soluble IFN-G R1 that binds IFN-G has been detected in biological fluids. The recombinant soluble IFN-G R1 has been shown to bind IFN-G with high affinity and is a potent IFN-G antagonist. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 0.1-0.4ug/ml ELISA (capture): 2-8ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2453-01G1
Reactivities: Mouse
Hosts: Goat
Conjugates: Biotin
Size: 50ug
Form: Supplied as a lyophilized powder in PBS, BSA. Reconstitute with sterile TBS, pH7.3 (20mM Trizma base, 150mM sodium chloride), 0.1% BSA to 200ug/ml. Labeled with Biotin.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Bach, E.A. et al. (1997) Annu. Rev. Immunol. 15:563.
Additional info: Recognizes mouse CD119.

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