Home  >  Products  >  CD11a (Integrin alpha-L, CD11 Antigen-like Family Member A, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, LFA-1A, Leukocyte Function-associated Molecule 1 alpha Chain, ITGAL)
CD11a (Integrin alpha-L, CD11 Antigen-like Family Member A, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, LFA-1A, Leukocyte Function-associated Molecule 1 alpha Chain, ITGAL)

CD11a (Integrin alpha-L, CD11 Antigen-like Family Member A, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, LFA-1A, Leukocyte Function-associated Molecule 1 alpha Chain, ITGAL)

Cat no: C2262-33U

Supplier: United States Biological
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CD11a is a 170-180kD type I transmembrane glycoprotein also known as LFA-1a chain and integrin aL subunit. CD11a non-covalently associates with integrin B2 (CD18) to form LFA-1. It is expressed on all leukocytes, including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. It is absent on non-hematopoietic tissues and platelets. CD11a plays a central role in leukocyte cell-cell interactions and is important in lymphocyte costimulation. CD11a/CD18 binds to ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). Applications: Suitable for use in Flow Cytometry, Western Blot, Blocking of Cell-cell Interaction and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.5ug/10e6 cells in 100ul Immunohistochemistry: acetone-fixed, frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2262-33U
Reactivities: Human, Bovine, Canine, Rabbit, Sheep
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W.1989. Leucocyte Typing IV. Oxford University Press, New York. 2. Leite, F., et al. 2002. Infec. Immun. 70:4336. 3. Jiang, Y., et al. 2005. Clin. Hemorheol. Microcircul. 32:261. 4. B
Additional info: Recognizes human CD11a. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, equine, bovine, sheep, canine, rabbit.

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