CD11a (Leukocyte Function Associated Antigen, LFA-1, Integrin aL)

CD11a (also known as integrin alphaL or lymphocyte function-associated antigen (LFA)-1 alpha chain) complex with the Beta2 subunit of the integrin family, CD18, to form the cell surface heterdimer, LFA-1 or CD11a /C18 (alphaLBeta2). LFA-1 is expressed on all leukocytes including lymphocytes, monocytes, and granulocytes. It is involved in leukocyte adhesion to its ligands including intercellular adhesion molecule-1 (ICAM-1 or CD54), ICAM-2 (CD102), ICAM-3 (CD50) and Telencephalin (TLN) and play a role in most immune/inflammatory responses. MAb DF1524 reacted with CD11a transfected cells and potently blocked LFA-1 dependent homotypic cell aggregation.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:16,000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2262-02A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by affinity chromatography.

Isotype

IgG

References

1. Stanley P, Smith A, McDowall A, Nicol A, Zicha D, Hogg N, Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell. The EMBO journal 2008 Jan 27 (1): 62-75.

Additional Info

Recognizes human CD11A/ Integrin Alpha L. Sequence homology: canine.