CD11b (CD11 Antigen-like Family Member B, Cell Surface Glycoprotein MAC-1 Subunit alpha, CR-3 alpha Chain, CR3A, Integrin alpha M, Integrin alpha-M, ITGAM, Leukocyte Adhesion Receptor MO1, Neutrophil Adherence Receptor)

The recognised antigen is a heterodimer (160 and 95kD) belonging to the family of adhesion molecules CD11b/CD18, also designated as Mac-1 antigen or CR3. Has been shown to induce homotypic aggregation of granulocytes.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications have not been tested. \n\nRecommended Dilutions: \nImmunohistochemistry: frozen sections. Not suitable for use in paraffin sections.\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2262-52M

Size

250ug

Applications

IHC

Hosts

Mouse

Reactivities

Rat

Form

Suppplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Damoiseaux, J.G.M.C. et al. (1989) Heterogeneity of macrophages in the rat evidenced by variability in determinants: two new anti-rat macrophage antibodies against a heterodimer of 160 and 95kD (CD11/CD18). J. Leukoc. Biol. 46: 556-564. 2. De Groot, C.J.A. et al. (1988) Discrimination between different types of neuroglial cells in rat central nervous system using combined immuno- and enzyme-histochemical methods. Immunobiology. 178: 177-190. 3. Dijkstra, C.D. and Damoiseaux, J.G.M.C. (1993) Macrophage heterogeneity established by immunocytochemistry. Prog. Histochem. Cytochem. 27: 1-65. 4. Huitinga, I. et al. (1993) Treatment with anti CR3 antibodies ED7 and ED8 suppresses experimental allergic encephalomyelitis in Lewis rats. Eur. J. Immunol. 23: 709-715. 5. Zilka, N. et al. (2009) Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy. J. Neuroimmunol. 209: 16-25.

Additional Info

Recognizes a membrane antigen on rat macrophages, monocytes, dendritic cells and granulocytes. It also recognises small ramified microglia in the central nervous system. No other cell types are positive.

Alternative Names

Integrin, alpha M (Complement Component 3 Receptor 3 Subunit)