Home  >  Products  >  CD11b (Integrin alpha-M, CD11 Antigen-like family Member B, CR-3 alpha Chain, Cell Surface Glycoprotein MAC-1 Subunit alpha, Leukocyte Adhesion Receptor MO1, Neutrophil Adherence Receptor, ITGAM, CR3A)
CD11b (Integrin alpha-M, CD11 Antigen-like family Member B, CR-3 alpha Chain, Cell Surface Glycoprotein MAC-1 Subunit alpha, Leukocyte Adhesion Receptor MO1, Neutrophil Adherence Receptor, ITGAM, CR3A)

CD11b (Integrin alpha-M, CD11 Antigen-like family Member B, CR-3 alpha Chain, Cell Surface Glycoprotein MAC-1 Subunit alpha, Leukocyte Adhesion Receptor MO1, Neutrophil Adherence Receptor, ITGAM, CR3A)

Cat no: C2262-51Q

Supplier: United States Biological
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CD11b is a 165-170kD type I transmembrane glycoprotein also known as aM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin B2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen and Factor X. This antibody inhibits heterotypic adhesion of granulocytes in response to fMLP. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, Blocking of Granulocyte Activation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.5ug/10e6 cells in 100ul of whole blood Immunohistochemistry: acetone-fixed, frozen tissue sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2262-51Q
Reactivities: Human, Porcine
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W. 1989. Leucocyte Typing IV. Oxford University Press, New York. 2. Barclay, N., et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego. 3. Rezzonico, R., et al. 2001. Blood 97:2932. 4. Marsik, C., et al. 2003. Shock 20:493. 5. David, A., et al. 2003. J. Leukoc. Biol. 74:551. 6. Charles, N., et al. 2010. Nat. Med. 16:701. (FC) 7. Thurlow, L.R., et al. 2010. Infect. Immun. 128:1128. 8. Jadhav, S., et al. 2001. Blood 167:5986. (Block) 9. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 10. Sestak, K., et al. 2007. Vet. Immunol. Immunop. 119:21. 11. Stewart, M., et al. 1995. Curr. Opin. Cell Biol. 7:690.
Additional info: Recognizes human CD11b. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, porcine.

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