CD133 (APC) (AC133, Antigen AC133, CD133, CD133 Antigen, CD133 Retinal Degeneration, CORD12, MCDR2, MSTP061, Prominin 1, Prominin-1, PROM1, PROM, Prominin-like Protein 1, PROML1, RP41, STGD4)

CD133 (also known as Prominin-1 or AC133) is a 120 kD pentaspan glycoprotein with 5 transmembrane domains which localize to cellular protrusions. CD133 was initially described as a surface antigen specific for human hematopoietic stem cells and as a marker for murine neuroepithelial cells and some embryonic epithelia. Later on, CD133 was found on other stem cells including endothelial progenitor cells, glioblastomas, neuronal, and glial stem cells. In addition to hematopoietic stem cells, CD133 was found on cancer cells, such as some leukemia cells and brain tumor cells. It also has been detected at low levels in the kidney, pancreas, placenta, and fetal liver tissue. Although the biological function of CD133 is not conclusive, CD133 has been extensively used as a stem cell marker for normal and cancerous tissues.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications have not been tested. \n\nRecommended Dilution:\nFlow Cytometry: 1.0ug / 10e6 cells in 100ul volume\nOptimal dilutions to be determined by researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.\n\n\n\n\n

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SPECIFICATIONS

Catalog Number

C2514-90J

Size

100ug

Applications

FC

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Labeled with Biotin.

P Type

Mab

Purity

Purified by affinity chromatography.

Isotype

IgG2a,l

References

1. Singh SK, et al. 2004. Nature 18:396. 2. Falini B, et al. 2005. New Engl. J. Med. 352:254. 3. Bonanno G, et al. 2004. Transfusion 44:1087. 4. Gaipa G, et al. 2002. Haematologica 87:347. 5. Wuchter C, et al. 2001. Haematologica 86:154. 6. Zhang Y, et al. 2012. Diabetes. 61:2114.

Additional Info

Recognizes mouse CD133.