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Products CD36 Monoclonal Antibody (Clone JC63.1)
| Catalogue number: | 188150 |
| Hosts: | Mouse |
| Applications: | Flow Cytometry |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | adenovirus expressing full-length recombinant mouse CD36 |
| P type: | Antibodies |
| Isotype: | IgA |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells and thereby atherosclerotic lesions. This membrane glycoprotein can internalize fatty acids which activate PPAR.gamma. and stimulate further expression of CD36. This positive feedback loop combined with the murine CD36 knock-out studies reinforces the importance of CD36 in lipid metabolism. Additionally CD36 is needed for the phagocytosis of P. falciparum infected erythrocytes, retinal pigment epithelial cell photoreceptor fragments, and post-apoptotic monocytes and neutrophils. CD36 expression has been monitored during hematopoietic cell differentiation and may be an indicator of tumor spreading in lymphocytic leukemia. Positive controls include cells from adipose and heart tissue, platelets, and macrophages. Cayman Chemical's CD36 monoclonal antibody is recommended for flow cytometry on CD36-containing cells of murine, rat, and human origin. The antibody can also be used to antagonize CD36-mediated cellular activity. The antibody does not work well for Western blot analysis of CD36. |
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