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CD40 (Q259) Peptide

Cat no: BS1458P

CD40 (Q259) Peptide

A receptor ligand pair central to the transmission of this signal is CD40, expressed on the surface of B cells, together with CD40L, expressed on activated T cells. In the presence of such stimulus, IL-4 and IL-13 are capable of triggering immunoglobulin class switching and secretion of IgE. B cells are sensitive to these cytokines only subsequent to CD40/CD40L-driven DNA synthesis. A downstream mediator of the CD40 signaling pathway, designated CRAF, is a member of an expanding family of proteins that contain a conserved cysteine- and histidine-rich RING finger motif. Other members of the family include TRAF1 and TRAF2. The latter proteins have been shown to regulate TNF-R2 as well as CD40 signaling through activation of the NFkB family of transcription factors.

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SPECIFICATIONS

Catalog Number

BS1458P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide CD40 (Q259). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P25942

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1458 CD40 (Q259) pAb.

Alternative Names

Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD40; CD40; TNFRSF5

SUPPLIER INFO

Bioworld Technology, Inc.

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