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CD45RO (Leukocyte Common Antigen, LCA, Ly-5 T200)

Cat no: C2400-74

CD45RO (Leukocyte Common Antigen, LCA, Ly-5 T200)

CD45 (leukocyte common antigen or LCA) is a 180-220kD glycoprotein composed of a single transmembrane region and a large cytoplasmic domain which has tyrosine phosphatase activity. The tyrosine phosphatase activity of CD45 plays a causal role in the lymphocyte activation and development. The intracellular domain is identical in the different isoforms. Several isoforms of CD45 have been described based on differential splicing of exons. The O isoform results from the post-translational change of the mRNA of the A, B, and C exons, and is known as CD45RO.\nMouse anti-CD45RO (clone: UCHL1) recognizes an epitope strongly expressed on the lower molecular weight isoform (p180) of the human CD45 family. UCHL1 is a useful marker of normal and neoplastic T-cells, macrophages, and granulocytic precursors. Benign B-cells, however, should have a negative result. Some intestinal intra-epithelial lymphocytes are also CD45RO negative. CD45RO is expressed by most T-lymphocytes, macrophages, and Langerhans

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SPECIFICATIONS

Catalog Number

C2400-74

Size

1ml

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, and 1% BSA with 0.1% sodium azide

P Type

Mab

Purity

Purified from mouse ascites

Isotype

IgG2a,k

Additional Info

Recognizes CD45RO

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

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Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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