Home  >  Products  >  CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)
CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)

CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)

Cat no: C2407-50K

Supplier: United States Biological
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The CD52 antigen is a remarkably small peptide that is heavily glycosylated, and attached to the cell surface membrane via a GPI link. The apparent molecular mass of the antigen on SDS-PAGE is 25-29kD. CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable.Humanised versions of CAMPATH-1 specific antibodies are currently in clinical trials for the treatment of a range of lymphoid malignancies. Applications: Suitable for use in Cytotoxicity Assays, ELISA, Flow Cytometry, Immunohistochemistry (frozen, resin, and paraffin), Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:20 Immunohistochemistry (paraffin): 1:20-1:40 Flow cytometry: 1:20 Cytotoxic Assays: 50ug/ml (Use human serum as complement source) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2407-50K
Reactivities: Human, Non-Human Primate
Hosts: Rat
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 200ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A affinity chromatography.
References: 1. Hale, G. et al. (1998) Improving the Outcome of Bone Marow Transplantation by using CD52 Monoclonal Antibodies to prevent graft-versus-host disease and graft rejection. Blood 92: 4581-4590 2. Salisbury, J.R. et al. (1994) Immunohistochemical analysis of CDw52 antigen expression in non-hodgkins lymphomas. J. Clin. Path. 47: 313 - 317.
Additional info: Recognizes human CD52. Species crossreactivity: Rhesus Monkey.

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