Home  >  Products  >  CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)
CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)

CD52 (CD52 Antigen, CD52 Molecule, CDw52, Cambridge Pathology 1 Antigen, CAMPATH 1, CAMPATH-1 Antigen, Epididymal Secretory Protein E5, HE5)

Cat no: C2407-50L

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
CD52 antigen, also known as CAMPATH-1. The CD52 antigen is a remarkably small peptide that is heavily glycosylated, and attached to the cell surface membrane via a GPI link. The apparent molecular mass of the antigen on SDS-PAGE is 25-29kDa.CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable.The CD52 antigen is a remarkably small peptide that is heavily glycosylated, and attached to the cell surface membrane via a GPI link. The apparent molecular mass of the antigen on SDS-PAGE is 25-29kDa. Humanised versions of CAMPATH-1 specific antibodies are currently in clinical trials for the treatment of a range of lymphoid malignancies. Applications: Suitable for use in Cytotoxicity Assays, Flow Cytometry, Immunohistochemistry (frozen), and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:20 Flow cytometry: 1:20 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2407-50L
Reactivities: Human, Non-Human Primate
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Mab
Isotype: IgM
Purity: Purified by ammonium sulfate precipitation.
References: 1. Hale, G. et al. (1985) Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation. Br. J. Haem. 80: 41-48.2. Hale, G. et al. (1998) Improving the Outcome of Bone Marow Transplantation by using CD52 Monoclonal Antibodies to prevent graft-versus-host disease and graft rejection. Blood 92: 4581-4590.3. Hale, G. et al. (1983) Effects of monoclonal anti lymphocyte antibodies in vivo in monkeys and humans. Mol. Biol. Med. 1: 321-334.4. Yoshino, N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp. Anim. 49: 97-110.
Additional info: Recognizes human CD52. Species crossreactivity: Cynomolgus monkey.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave