CD8A pAb

The T cell receptor (TCR) is a heterodimer composed of either (alpha) and (beta) or (gamma) and (delta) chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins, while T cytotoxic cells display CD8. CD8 (also designated Leu-2 or T8), a cell surface glycoprotein, is a two chain complex ((alpha)(alpha) or (alpha)(beta)) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.

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SPECIFICATIONS

Catalog Number

BS60357

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

A synthetic peptide corresponding to residues in Human CD8A.

Species

CD8A pAb detects endogenous levels of CD8A protein.

Dilutions

WB: 1:500~1:1000\r

Swiss Prot

P01732

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul