Cflar, ID (Clarp1, Dr.82387)

Cat no: C2087-43

Supplier: United States Biological

0 reviews | Write a Review Pencil

Read More on Supplier Website

Description
Additional Information

CASP8 AND FADD-like apoptosis regulator (Cflar) may function as a crucial link between cell survival and cell death pathways in mammalian cells. It as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. It lacks enzymatic (caspase) activity. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: C2087-43M Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C2087-43
Reactivities:	Zebrafish/Fish
Hosts:	Rabbit
Applications:	ELISA
Size:	250ul
Form:	Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.1% sodium azide, 50% glycerol.
P type:	Pab
Isotype:	IgG
Purity:	Purified by immunoaffinity chromatography.
References:	1. P M Eimon, et al. Cell Death and Differentiation (2006) 13, 1619-1630. 2. http://www.uniprot.org/uniprot/O15519.
Additional info:	Recognizes zebrafish Cflar.

See Full Product Listings >

Cflar, ID (Clarp1, Dr.82387)

Cat no: C2087-43

Get Quote

About Biosave

Product Categories

Information


Get a Quote Direct from United States Biological




By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*