CGB (CGB8, Choriogonadotropin subunit beta, Chorionic gonadotrophin chain beta)

Human chorionic gonadotropin beta (CGB) belongs to the glycoprotein hormone family that includes the beta subunit of lutenizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) (1). These hormones are central to the endocrine system that regulates normal growth, sexual development, and reproductive function (2). HCG primarily maintains the myometrial and decidual spiral arteries, or the vascular supply of the placenta during the full course of pregnancy (3). It is mainly secreted by the endocrine villous cytotrophoblasts into the maternal compartment and stimulates the formation of the syncytiotrophoblast in an autocrine manner (4). Then HCG binds to the corpus luteum of the ovary, which is stimulated to produce progesterone and maintain the secretory endometrium (5). CGB confers biological specificity, whereas the alpha subunit of HCG is common to all glycoprotein hormones (1).\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry: 1:100-250\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. \n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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SPECIFICATIONS

Catalog Number

045609

Size

100ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, sodium azide, BSA, glycerol.

P Type

Mab

Purity

Supernatant

References

1. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2009). 2. Godine et al. J. Biol. Chem. 257:8368-71,1982. 3. Cole LA. Expert Rev Mol Diagn. 9(7):721-47, 2009. 4. Handschuh K et al. Placenta. 30(12):1016-22, 2009. 5. Stenman UH et al. Hum Reprod Update. 12(6):769-84, 2006.

Additional Info

Recognizes human CGB.