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CHD4 (CHD-4, Chromodomain Helicase DNA Binding Protein 4, Mi-2b, MI2-beta, Mi2 Autoantigen 218kD Protein)

CHD4 (CHD-4, Chromodomain Helicase DNA Binding Protein 4, Mi-2b, MI2-beta, Mi2 Autoantigen 218kD Protein)

Cat no: C3880-25C

Supplier: United States Biological
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The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. CHD4/Mi2beta is a helicase component of the nucleosome remodeling and deacetylase (NuRD) complex that functions to remodel chromatin and repress transcription. Outside of the NuRD complex, CHD4/Mi2beta can function as an activator of transcription in association with p300 histone acetyltransferase. Alternate names for CHD4/Mi2beta include chromodomain-helicase-DNA-binding protein 4, CHD-4, ATP-dependent helicase CHD4, Mi-2 autoantigen 218kD protein, Mi2-beta, Mi-2b and DKFZp686E06161. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:2000-1:10,000 Immunoprecipitation: 2-5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C3880-25C
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in TBS, pH 7.2, 0.1% BSA, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CHD-4, Chromodomain helicase DNA binding protein 4, Mi-2b, MI2-beta, Mi2 autoantigen 218kD protein
Additional info: Recognizes human CHD4/Mi2 beta. Species Crossreactivity: Mouse.

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