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Chk1, CT (CHEK1, Cell Cycle Checkpoint Kinase)

Cat no: C4200-05A

Chk1, CT (CHEK1, Cell Cycle Checkpoint Kinase)

Chk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression (1). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (2). Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c (3,4). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase (3, 4).\n\nApplications: \nSuitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 1:160\nWestern Blotting: 1:10,000\nImmunohistochemistry: 1:250

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SPECIFICATIONS

Catalog Number

C4200-05A

Size

100ul

Applications

FC, ICC, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1.Martinho RG, et al. EMBO J. 17:7239-7249, 1998. 2.Zhao H, et al. Mol Cell Biol 21:4129-4139, 2001.\n3.Zeng Y, et al. Nature 395:507-510, 1998. 4.Sanchez Y, et al. Science 277:1497-1501, 1997.

Additional Info

Recognizes human Chk1

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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