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Chk2, phosphorylated (Ser33/35) (Checkpoint Kinase 2, Rad 53)

Chk2, phosphorylated (Ser33/35) (Checkpoint Kinase 2, Rad 53)

Cat no: C4201-32B

Supplier: United States Biological
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Chk2 is a checkpoint kinase that plays a role in regulating cell cycle progression. In response to DNA damage and DNA replicational stress, Chk1 and Chk2 phosphorylate Cdc25C to prevent entry into mitosis (1,2). Consisting of ionizing radiation (IR), UV irradiation or hydroxyurea treatment, DNA damage induces ATM/ATR to phosphorylate Thr68 and other sites in the amino terminal domain (3). Phosphorylation at Thr68 is a prerequisite for subsequent activation steps. Applications: Suitable for use in Immunocytochemistry, Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500 Immunocytochemistry: 1:100 -250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C4201-32B
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Blasina, A., et al. Curr Biol. 9: 1
Additional info: Recognizes Chk2 phosphorylated on Serine 33/35.

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