Choline Acetyltransferase (Choline O-acetyltransferase, CHOACTase, ChAT, Choline Acetylase, CMS1A, CMS1A2)

Choline Acetyltransferase (ChAT) is an enzyme that catalyzes the synthesis of acetylcholine from choline and acetyl coenzyme A, and is found in cholinergic neurons in the CNS. Interestingly, specific loss of cholinergic neurons has been reported in the basal forebrain in Lewy Body Dementia and Alzheimer

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SPECIFICATIONS

Catalog Number

C5057-09C

Size

1ml

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a lyophilized powder in 15mM sodium azide. Reconstitute with 1ml dH2O.

P Type

Mab

Purity

Supernatant

Isotype

IgG1,k

References

1.Lippa CF, Smith TW and Perry E. Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology. J. Neural Transm. 105(5-6):525-535 (1999). 2.Grosman DD, Lorenzi MV, Trinidad AC, et al.. The human choline acetyltransferase gene encodes two proteins. J. of Neurochemistry 65:484-491 (1995). 3.Benecke S, Ostermann-Latif C, Ma?der M, et al.. Antibodies raised against synthetic peptides react with choline acetyltransferase in various immunoassays and in immunohistochemistry. J. of Neurochemistry 61:804-811 (1993). 4.Oda Y, Nakanishi I and Deguchi T. A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells. Molecular Brain Research 16:287-294 (1992).

Additional Info

Recognizes Choline Acetyltransferase. Species Crossreactivity: Human.

Alternative Names

Acetyl CoA:choline O-acetyltransferase, Choline O Acetyltransferase, EC=2.3.1.6