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CHOP (C/EBP Homology Protein, GADD153, Growth Arrest and DNA Damage Inducible Protein 153)

CHOP (C/EBP Homology Protein, GADD153, Growth Arrest and DNA Damage Inducible Protein 153)

Cat no: C5064-05

Supplier: United States Biological
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CHOP is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP a and b. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP-CHOP dimer gains binding activity to other non-classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of CHOP inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C5064-05
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Liquid. Purified antibody in PBS containing 1mg/ml BSA and 0.05% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified
References: 1. N. Batchvarova, et al.; EMBO J. 14, 4654 (1995) 2. X.Z. Wang, et al.; Mol. Cell. Biol. 16, 4273 (1996) 3. S. Saisanit and X.H. Sun; Mol. Cell. Biol. 17, 844 (1997) 4. X.Z. Wang, et al.; EMBO J. 17, 3619 (1998) 5. X.Z. Wang, et al.; EMBO J. 17, 5708 (1998) 6. M. Kuroda, et al.; PNAS 96, 5025 (1999) 7. J. Sok, et al.; Mol. Cell. Biol. 19, 495 (1999)
Additional info: Recognizes human and mouse CHOP. Detects a band of ~3kD by Western blot.

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