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Chorionic Gonadotropin, Human (hCG)

Chorionic Gonadotropin, Human (hCG)

Cat no: C5069-01C1

Supplier: United States Biological
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Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma. Cellular Localization: Cytoplsmic Applications: Suitable for use in Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C5069-01C1
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: May contain azide. See Certificate of Analysis.
P type: Pab
Purity: Purified by Protein A affinity chromatography.
Alternative names: Human Chorionic Gonadotropin
References: Morrish DW et al. Demonstration of specific secretory granules for human chorionic gonadotropin in placenta. J Histochem Cytochem 35:93-101 (1987). Mehta HC & MacDonald DJ A sensitive enzyme immunoassay specific for human chorionic gonadotrophin. Clin Chim Acta 121:245-50 (1982).
Additional info: This antibody reacts with hCG. It stains strongly with the human placenta and placental trophoblasts. No non-specific stainingwith any other tissue has been observed. Species Crossreactivity: Crossreacts with Human.

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