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CHP2 Peptide

Cat no: BS5661P

CHP2 Peptide

CHP2 (Calcineurin B homologous protein 2), also known as Hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains four EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.

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SPECIFICATIONS

Catalog Number

BS5661P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide CHP2. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O43745

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5661 CHP2 pAb.

Alternative Names

Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520; HCA520

SUPPLIER INFO

Bioworld Technology, Inc.

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