Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI)

Chromogranin A (CgA) is a 49kD protein which is a member of the granin/secretogranin family of acidic glycoproteins. It is specifically expressed in all endocrine and neuroendocrine cells and plays multiple roles in the process of regulated secretion of peptide hormones and neurotransmitters. Owing to its over-expression in several tumors of neuroendocrine origin, CgA is of diagnostic value in classical endocrine, in hormone-negative and in neuroendocrine tumors.\n\nApplications: \nSuitable for use in ELISA and Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:200-1:400\nFlow Cytometry: 1.2ug/1x1056 cells\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. \n

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SPECIFICATIONS

Catalog Number

C5069-96K

Size

100ug

Applications

ELISA, FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Purity

Purified by Protein G chromatography.

Isotype

IgG1

References

1. Hendy GN, Bevan S, Mattei MG, Mouland AJ (1995). Chromogranin A. Clin Invest\nMed;18(1):47-65. 2. Deftos LJ (1991). Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker. Endocr Rev; 12(2):181-7.

Additional Info

Recognizes human Chromogranin A.