Chromogranin A (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI)

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.\n\nApplications: \nSuitable for use in ELISA (peptide) and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA (peptide): 1:4000 (detection limit).\nWestern Blot: 0.1-0.3ug/ml. ~ 50kD band observed in human kidney lysates (calculated MW of 50.7kD according to NP_001266.1).\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: Human Kidney lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C5069-97D

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris-saline, pH7.3, containing 0.5% BSA and 0.02% sodium azide

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Li L, Yuan YZ, Lu J, Xia L, Zhu Y, Zhang YP, Qiao MM. , Treatment of pancreatic carcinoma by adenoviral mediated gene transfer of vasostatin in mice. ,Gut. 2006 Feb;55(2):259-65. Epub 2005 Nov 15., PMID: 16287901

Additional Info

Recognizes human Chromogranin A

Alternative Names

CGA, CHG A, Chromogranin A parathyroid secretory protein 1, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI