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CLAC-P, NC2-1 Region (Collagen-like Alzheimer Amyloid Plaque Component)

CLAC-P, NC2-1 Region (Collagen-like Alzheimer Amyloid Plaque Component)

Cat no: C5819-50B

Supplier: United States Biological
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Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100kD polypeptides in Alzheimer's disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C5819-50B
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: As reported
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: Collagen-like Alzheimer Amyloid Plaque Component
References: 1. Hashimoto,T. et. al. EMBO J. 21 (7), 1524-1534 (2002).
Additional info: Reacts with residues 171-183 [NHGFLSADQQLIK] of the NC2-1 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100kD in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy. Species Crossreactivity: Human and mouse. Other species have not been tested.

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