Claudin 6/9

Claudin 6 and Claudin 9 belong to the claudin family which constitutes a large group of four-transmembrane domain proteins (1). Claudins are integral tight junction proteins that are responsible for maintaining the integrity of epithelial cell architecture, the control of paracellular transport and cell polarity. The expression pattern of claudins is tissue specific, most tissues express multiple claudins, which can interact in both homotypic and heterotypic fashion to form the tight junction strands (2). Several claudin proteins have been shown to be abnormally expressed in cancers. The differential expression of these proteins between tumour and normal cells, in addition to their membrane localisation, makes them prime candidates for cancer therapy (2). Members of the claudin family, including Claudin 6 and 9 are expressed in the liver and play a critical role in Hepatitis C Infection. They function as coreceptors in HCV entry and assume a role in HCV dissemination, replication and pathogenesis (3). \n\nApplications: \nSuitable for use in Flow Cytometry, ELISA and ELISA. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 1.2ug/10e6 cells\nELISA: 1:200-1:400\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

167730

Size

100ug

Applications

ELISA, FC

Hosts

Rat

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

igG2b

References

1. Kazumasa M, Mikio F, Kazushi F, Shoichiro T (1999). Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A. 19; 96(2): 511

Additional Info

Recognizes rat Claudin 6/9. Recognizes the complete native protein expressed on transfected mammalian cells.