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Cleaved-Lamin A (D230+) pAb

Cleaved-Lamin A (D230+) pAb

Cat no: BS7014


Supplier: Bioworld Technology, Inc.
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Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear disregulation and cell death.
Catalogue number: BS7014
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P02545
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 231-280 of Human Lamin A.
Species: Cleaved-Lamin A (D230+) pAb detects the large fragment of lamin A (50 kDa)and lamin C (45 kDa) resulting from cleavage at Asp230. The antibody does not cross-react with full length lamin A or lamin C.
Molecular weight: ~ 45, 50 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C
Additional info: For research use only, not for use in diagnostic procedure.

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