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Cleaved-Notch 1 (V1754) Peptide

Cleaved-Notch 1 (V1754) Peptide

Cat no: BS7018 P

Supplier: Bioworld Technology, Inc.
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Notch1 is a transmembrane protein functioning in development and the determination of cell fate. During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain. Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1753 and Val1754. The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription.
Catalogue number: BS7018 P
Applications: Block/Neutralize/Inhibit
Swiss prot: P46531
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide Cleaved-Notch 1 (V1754). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Notch1 intracellular domain NICD
Additional info: This peptide can be used with studies using BS7018 Cleaved-Notch 1 (V1754) pAb.

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