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Cleaved-Notch 2 (A1734) Peptide

Cleaved-Notch 2 (A1734) Peptide

Cat no: BS7043P


Supplier: Bioworld Technology, Inc.
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The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions.
Catalogue number: BS7043P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q04721
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide Cleaved-Notch 2 (A1734). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Neurogenic locus notch homolog protein 2; Notch 2; hN2; Notch 2 extracellular truncation; Notch 2 intracellular domain; NOTCH2
Additional info: This peptide can be used with studies using BS7043 Cleaved-Notch 2 (A1734) pAb.

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