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Cleaved-PARP-1 (D214) Peptide

Cleaved-PARP-1 (D214) Peptide

Cat no: BS7047P


Supplier: Bioworld Technology, Inc.
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PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.
Catalogue number: BS7047P
Applications: Block/Neutralize/Inhibit
Swiss prot: P09874
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide Cleaved-PARP-1 (D214). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: PARP1; ADPRT; PPOL; ADPRT 1; ARTD1; Poly [ADP-ribose] polymerase 1; ADP-ribosyltransferase diphtheria toxin-like 1
Additional info: This peptide can be used with studies using BS7047 Cleaved-PARP-1 (D214) pAb.

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