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CLIMP63 (Cytoskeleton-Linking Membrane Protein of 63kD, ER Protein p63)

CLIMP63 (Cytoskeleton-Linking Membrane Protein of 63kD, ER Protein p63)

Cat no: C5840-93

Supplier: United States Biological
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The 63kD cytoskeleton-linking membrane protein (CLIMP-63) is a marker for the reticular subdomain of the rough endoplasmatic reticulum (ER) and is excluded from the outer nuclear membrane. Concentration of CLIMP-63 into patches may enhance microtubule binding on the cytosolic side and contribute to ER morphology by the formation of a protein scaffold in the lumen of the ER, linking the rough ER to microtubules. Applications: Suitable for use in ELISA, Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Immunohistochemistry and Western Blot. Other applications have not been tested. Recommended Dilutions: Immunoprecipitation: 2ul Immunocytochemistry: 1:1000 Immunohistochemistry: Frozen sections Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS, 0.1% sodium azide. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C5840-93
Reactivities: Human, Non-Human Primate
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder. Reconstitute with 100ul sterile PBS, 0.1% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography and gel filtrated (FPLC), (same/more than)95%.
References: 1. Schweizer, A., et al., J. Cell Sci. 104: 671 (1993). 2. Schweizer, A., et al., J. Cell Sci. 104: 685 (1993). 3. Schweizer, A., et al., J. Cell Biol. 126: 25 (1994). 4. Schweizer, A., et al., J. Cell Sci. 108: 2477 (1995). 5. Klopfenstein, D.R., et al., EMBO J. 17: 6168 (1998). 6. Klopfenstein, D.R., et al., J. Cell Biol. 153: 1287 (2001). 7. Breuza, L., et al., J. Biol. Chem. 279: 47,242 (2004).
Additional info: Recognizes human CLIMP63. Species Crossreactivity: monkey

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