Clostridium difficile Toxin B

Clostridium difficile is a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density and the administration of antibiotics. Toxin B (TcdB) is a large exotoxin. Its role in disease is less well understood than that of toxin A, though it seems clear that TcdB contributes to disease. Both toxins modifies the Ras superfamily of small GTPases via glycosylation, inactivating them and leading to the disruption of vital signaling pathways in the cell.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C5856-01B

Size

500ul

Applications

ELISA

Hosts

Mouse

Form

Supplied as a liquid, 0.1% sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgG1,k

Additional Info

Recognizes Clostridium difficile Toxin B. Crossreactivity: Reacts with 3 strains of C. difficile, Strain ID# 43255, 24050, 26689, as well as C. sordelli strain # 2037. Does not react with C. absonum, C. barati, C. botulinum, C. butyricum, C. carnis, C. celatum, C. chauvoei, C. colinum, C. hastiforme, C. histolyticum, C. innocuum, C. irregularis, C. leptum, C. limosum, C. malenominatum, C. novyi, C. peffringens, C. septicum, C. sporogenes, C. tetani, C. tertium or C. difficile Strain ID # 2037, B. assacchrolyhcus, B. adolescentis, P. productus, R. brommii, M. elsdenii, E. coli, E. rectale, C. albicans, V. parvula, C. davisae, S. aureus and D. pigra.