Cochlioquinone A (Luteoleersin)

Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has been recently shown to be an antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). It is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase.\n\nPurity: >99% by HPLC\n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO.\n\nRelated to: Cochlioquinone B

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SPECIFICATIONS

Catalog Number

C7505-15

Size

500ug

Purity

: >99% by HPLC\n\n

References

1. Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from \nBipolaris brizae and Stachybotrys chartarum. Yoganathan K. et al. J. Antibiot. 2004, 57, 59. \n2. Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. Jung H.J. et al. Bioorg. Med. \nChem. 2003, 11, 4743. \n3. Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1. Lee H.B. et al. J. \nAntibiot. 2003, 56, 967. \n4. Phytotoxic compounds cochlioquinones are inhibitors of mitochondrial NADH-ubiquinone reductase. \nLim C.-H. et al. J. Pesticide Sci. 1996, 21, 213.

Alternative Names

Luteoleersin