Home  >  Products  >  Complement C3b, inactivated (iC3b, Complement Component 3, C3, AHUS5, ARMD9, ASP, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 1, CPAMD1)
Complement C3b, inactivated (iC3b, Complement Component 3, C3, AHUS5, ARMD9, ASP, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 1, CPAMD1)

Complement C3b, inactivated (iC3b, Complement Component 3, C3, AHUS5, ARMD9, ASP, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 1, CPAMD1)

Cat no: C7850-13V

Supplier: United States Biological
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Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis. Applications: Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilutions: Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Positive Control: Kidney from post streptoccal glomerulonephritis patients Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7850-13V
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in borate buffered saline, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A affinity chromatography.
References: 1. Janssena, B. et al. (2007) Molecular Immunology. 44: 3-10. 2. Bergmann-Leitner, E. et al. (2006) Clinical Immunology121: 177-185. 3. Sohn, J. H. et al. (2003) Nature Medicine 9: 206-212.
Additional info: Recognizes 42kD human inavtivated comploement component 3b (iC3b) neoantigen present in blood serum.

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