Connexin 43 (Connexin-43, Cx43, Cxn-43, Gap Junction 43 kD Heart Protein, Gap Junction alpha-1 Protein, Gap Junction Protein alpha 1, Gja1, MGC93610)

Connexin 43 (Cx43) is a member of the connexin gene family and a structural component of gap junctions. Gap junction plaques consist of clusters of intercellular aqueous channels that permit bidirectional passage of ions, metabolites, and molecules of size up to 1kD between two neighboring cells and have been implicated to be important in the control of cell proliferation, differentiation, and regeneration. GJs also mediate electrical and metabolic coupling and ensure coordinated activity in organs such as the heart. Cx43 is the main constituent of the GJ in working cardiomyocytes, and has been the subject of numerous investigations in the context of adult cardiac function and maintenance of proper rhythm. It is believed to function as a tumor suppressor gene. Its overexpression in cancer cell lines, has been found to reduce growth and oncogenicity to varying degrees. It exists in a phosphorylated state in both neonatal and adult cardiomyocytes. It has been mapped to chromosome 6q21-q23.2. It is expressed in the heart and fetal cochlea. Pathological role of Cx43 has been implicated in autosomal dominant oculodentodigital dysplasia, syndactyly type III and left heart syndrome.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHeart\n\nCellular Localization: \nCytoplasmic\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts