CPE (D305) pAb

CPN is a tetrameric complex consisting of two identical regulatory subunits (CPN reg) and two identical catalytic subunits (CPN cat). CPN reg is a member of the leucine-rich repeat family of proteins and CPN cat is a member of the regulatory B-type carboxypeptidase group. Carboxypeptidase E (CPE) is important for removing any remaining C-terminal Arg or Lys after initial endoprotease cleavage during prohormone processing. CPE is also crucial in proinsulin processing, and required for normal-sized photoreceptor synaptic terminal and normal signal transmission to the inner retina.

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SPECIFICATIONS

Catalog Number

BS3826

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 270-320 of Human CPE.

Species

CPE (D305) pAb detects endogenous levels of CPE protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

P16870

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 53 kDa

Alternative Names

Carboxypeptidase E; Carboxypeptidase H; Carboxypeptidase H precursor; CarboxypeptidaseE; CarboxypeptidaseH; CBPE; Cobalt stimulated chromaffin granule carboxypeptidase; CPE; Cph 1; CPH; Cph1; Enkephalin convertase; Entephalin convertase; Insulin granule associated carboxypeptidase; Prohormone processing carboxypeptidase; Prohormone-processing carboxypeptidase