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CRF (R153) pAb

CRF (R153) pAb

Cat no: BS2869


Supplier: Bioworld Technology, Inc.
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Individuals suffering from Alzheimer's disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression of CRF receptors (CRFRs) and abnormalities in neuronal morphology in affected brain areas. In addition, AD patients show decreased concentrations of CRF in their cerebrospinal fluid, which may contribute to their cognitive impairment. A high affinity CRF binding protein, designated CRF-BP, has been discovered in post-mortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of
Catalogue number: BS2869
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P06850
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 121-170 of Human CRF.
Species: CRF (R153) pAb detects endogenous levels of CRF protein.
Molecular weight: ~ 21 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone; CRH
Additional info: For research use only, not for use in diagnostic procedure.

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