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CRP Peptide

Cat no: BS60395P

CRP Peptide

Pentraxins, which include C-reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase proteins. CRP and SAP are produced by liver epithelial cells and are characterized by a cyclic pentameric structure and calcium-dependent ligand binding. IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction. Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene. During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes. Both Stat3 and C/EBP are involved in mouse SAP gene expression, but only Stat3 is involved in mouse CRP gene expression. SAP binds to a variety of molecules, including autoantigens and chromatin.

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SPECIFICATIONS

Catalog Number

BS60395P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide CRP. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P02741

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS60395 CRP pAb.

Alternative Names

C reactive protein; C reactive protein pentraxin related; C-reactive protein(1-205); CRP; CRP; CRP; MGC88244; Pentraxin 1; PTX 1; PTX1;

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