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Crystallin-(alpha)B (F15) pAb

Crystallin-(alpha)B (F15) pAb

Cat no: BS1625

Supplier: Bioworld Technology, Inc.
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(alpha)-crystallins consist of three gene products, (alpha)A, (alpha)B and (alpha)C-crystallin, which are members of the small heat shock protein family (HSP 20). They are induced by heat shock, and act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, (alpha)-crystallins do not renature these proteins. Expression of (alpha)A-crystallin is restricted to the lens. Defects in this gene cause autosomal dominant congenital cataracts (ADCC). The human (alpha)B-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of (alpha)B-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
Catalogue number: BS1625
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P02511
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 1-50 of Human Crystallin-(alpha)B.
Species: PP1(alpha) (G315) pAb detects endogenous levels of PP1(alpha) protein.
Molecular weight: ~ 20 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Alpha-crystallin B chain; Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component; CRYAB; CRYA2; (alpha)B-Crystallin
Additional info: For research use only, not for use in diagnostic procedure.

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