CSE1L (E2) pAb

Normal tissues are characterized by a balance between cellular stasis, cell proliferation, cell differentiation and cell death. Aberrant regulation of any of these cell processes can result in cancer. Cell death during embryogenesis, tissue atrophy and normal tissue turnover is called apoptosis. This is characterized by cytoplasmic and nuclear condensation, nuclear disorganization and fragmentation of genomic DNA into 180-200 base pair oligomers. Several human cDNA fragments have been shown to render MCF-7 cells resistant to cell death induced by Pseudomonas exotoxin, Pseudomonas exotoxin-derived immunotoxins, diptheria toxin and tumor necrosis factor (TNF). One such fragment has proven to be the human homolog to the yeast chromosome segregation homolog, CSE1. Cloning of the full-length human cDNA has revealed a putative protein designated CAS, for cellular apoptosis susceptibility, that is 971 amino acids in length with 59% overall sequence homology as compared to yeast CSE1. CAS is highly expressed in testis and fetal liver.

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SPECIFICATIONS

Catalog Number

BS1080

Size

100ug/100ul

Applications

IF, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids N-terminus of Human CSE1L.

Species

CSE1L (E2) pAb detects endogenous levels of Exportin-2 protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200\nIP: 1:50~1:200\nIF: 1:50~1:200

Swiss Prot

P55060

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 110 kDa

Alternative Names

Exportin 2; Exportin2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter; CSE1L; CAS; XPO2