CSF2RA pAb

The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common (beta) subunit. The a subunits are low affinity ligand binding proteins while the (beta) subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits. In contrast, the mouse IL-3 receptor has two distinct (beta) subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine (beta)-subunits are 91% homologous at the amino acid level but only 56% homologous to the human (beta) subunit. Although neither the murine nor the human (beta) subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.

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SPECIFICATIONS

Catalog Number

BS6570

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human CSF2RA.

Species

CSF2RA pAb detects endogenous levels of CSF2RA protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P15509

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 46 kDa

Alternative Names

CD116; CD116 antigen; CDw116; Colony stimulating factor 2 receptor alpha chain; CSF 2R; CSF2R; CSF2RA; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM CSF R alpha; GM CSF receptor alpha subunit; GM-CSF-R-alpha; GMCSFR; GMCSFR-alpha; GMR-alpha; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha;