CTPS (K109) pAb

CTPS (cytidine-5-prime-triphosphate synthase) is a 591 amino acid protein that contains one glutamine amidotransferase type-1 domain and is involved in pyrimidine metabolism. CTPS catalyzes the ATP-dependent conversion of UTP to CTP, a rate-limiting reaction that requires either ammonia or L-glutamine as a nitrogen source. Via its catalytic activity, CTPS plays an important role in the synthesis of nucleic acids and is crucial for proper cell growth and development. The function of CTPS is regulated by a variety of mechanisms, including phosphorylation by protein kinase C (PKC), an event that can either stimulate or inhibit CTPS activity. The gene encoding CTPS is located in a region on chromosome 1 that is often associated with the progression of several tumor types, suggesting a possible role for CTPS in tumorigenesis.

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SPECIFICATIONS

Catalog Number

BS2871

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 80-130 of Human CTPS.

Species

CTPS (K109) pAb detects endogenous levels of CTPS protein.

Dilutions

WB: 1:500~1:1000\r\nIHC: 1:50~1:200

Swiss Prot

P17812

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul