Cyclin D3 (G277) Peptide

Cat no: AP0379P

Supplier: Bioworld Technology, Inc.

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The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to affect progression through the restriction point and Rb-dependent entry into S-phase. The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of protein expression and phosphorylation-dependent degradation.Although the D-type cyclins are not fully redundant, cyclin D3, like D1, plays a prominent role in differentiation and proliferation, which correlates with higher expression levels of cyclin D3 in various cancers.

Catalogue number:	AP0379P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P30281
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Cyclin D3 (G277). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	CCND 3; CCND3; CyclinD3; Cyclin-D3; D3 type cyclin; G1 S specific cyclin D3; G1/S specific cyclin D3; G1/S-specific cyclin-D3;
Additional info:	This peptide can be used with studies using AP0379 Cyclin D3 (G277) pAb.

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Cyclin D3 (G277) Peptide

Cat no: AP0379P

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