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CYP1B1 Peptide

Cat no: BS5681P

CYP1B1 Peptide

Cytochrome P450 1B1 (CYP1B1) is a key enzyme involved in the production of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens and is the predominant member of the CYP1 family expressed in normal breast tissue and breast cancer. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). CYP1B1 catalyzes the conversion of 17-beta-estradiol to the catechol estrogen metabolites 2-OH-E2 and 4-OH-E2 which have both been postulated to be involved in mammary carcinogenesis. Genetic polymorphisms in CYP1B1 may play an important role in human prostate carcinogenesis as well. Polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with a change in catalytic function.

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SPECIFICATIONS

Catalog Number

BS5681P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide CYP1B1. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q16678

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5681 CYP1B1 pAb.

Alternative Names

Cytochrome P450 1B1; CYPIB1; CYP1B1

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