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CYP1B1 Peptide

CYP1B1 Peptide

Cat no: BS5681P

Supplier: Bioworld Technology, Inc.
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Cytochrome P450 1B1 (CYP1B1) is a key enzyme involved in the production of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens and is the predominant member of the CYP1 family expressed in normal breast tissue and breast cancer. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). CYP1B1 catalyzes the conversion of 17-beta-estradiol to the catechol estrogen metabolites 2-OH-E2 and 4-OH-E2 which have both been postulated to be involved in mammary carcinogenesis. Genetic polymorphisms in CYP1B1 may play an important role in human prostate carcinogenesis as well. Polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with a change in catalytic function.
Catalogue number: BS5681P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q16678
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide CYP1B1. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Cytochrome P450 1B1; CYPIB1; CYP1B1
Additional info: This peptide can be used with studies using BS5681 CYP1B1 pAb.

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